NADA Sham Relaxation 50 50 State Anxiety score State Anxiety score State Anxiety score 40 40 Before Session After Session Before Session After Session Before Session After Session Session Timing Session Timing Session Timing 12. The boxplots show the unadjusted comparisons of the anxiety score distributions before and after the treatment sessions for each of the 3 treatments. The authors do not provide any adjusted comparisons in the manuscript. Is this appropriate, or did they blatantly ignore a high potential for confounding? 13. Based on the boxplots, what conclusion can you make about the efficacy of acupuncture on anxiety reduction as compared to the other two groups? 14. What additional graphic would you need to see in order to ascertain whether the relationship between anxiety scores and acupuncture (as compared to relaxation therapy) is potentially modified by sex