Question
Need ANSWER FOR PART B !!!!!!!!!!!! 3) To design a crystallization process, an API was mixed with a given solvent in different proportions. It was
Need ANSWER FOR PART B !!!!!!!!!!!!
3) To design a crystallization process, an API was mixed with a given solvent in different proportions. It was found that the solubility curve can be described by the natural exponential function C=a.e(b.T) where a,b are constants, C is the concentration of API in mg/ml, and T is the temperature in Celsius. The constants a,b are such that a= 4.9 and b=0.0374 and thus C = 4.9e(0.0374T) = 4.9exp[0.0374T]. a. Mixtures of the API were cooled down at a very slow rate (0.01oC/min). The appearance of first crystals during the cooling step is given by C=25e0.0385T (where C is the concentration of API in mg/ml and T the temperature in Celsius). What does this curve represent? b. Plot the solubility curve and the curve given in part a. Do not sketch, plot using a graphing program. For your plot choose a temperature range that could reasonably be used for a pharmaceutical crystallization. Based on this plot, suggest a crystallization (cooling, anti-solvent or evaporative) scheme for this API. Give reasons for your answer.
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