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Recent Developments

On November 19, 2021, Vertexannounced that the "Spanish government has approved

terms for the national reimbursement of KAFTRIO(ivacaftor/tezacaftor/elexacaftor) in a

combination regimen with ivacaftor for the treatment of cystic fibrosis (CF) for eligible patients.

The agreement covers people with CF ages 12 years and older who have at least one copy of the

F508del mutation, regardless of the other mutation type in the CFTR gene. KAFTRIO

(ivacaftor/tezacaftor/elexacaftor) in a combination regimen with ivacaftor can be prescribed to

eligible patients by treating physicians once the medicine is listed in the national Official Gazette

Nomenclator"(Vertex Announces Reimbursement Agreement in Spain for KAFTRIO

(Ivacaftor/Tezacaftor/Elexacaftor) in Combination with Ivacaftor to Treat People with Cystic

Fibrosis 12 Years and Older With At Least One F508del Mutation in the CFTR Gene, 2021).

On March 26, 2022, Vertex announced that as of "1 April 2022, TRIKAFTA

(elexacaftor/tezacaftor/ivacaftor and ivacaftor) will be reimbursed on the Australian

Pharmaceutical Benefits Scheme (PBS) for the treatment of cystic fibrosis (CF) in people ages

12 years and older who have at least one F508del mutation in the CFTR gene, the most common

CF-causing mutation worldwide. "As a genetic disease, cystic fibrosis is a prime candidate for

precision medicine. Now, with PBS listing of TRIKAFTA, eligible Australians living with CF

ages 12 years and older can broadly access a therapy that treats the underlying cause of their

disease. Clinicians across Australia will be excited about this most welcome news," said

Professor John Wilson AM, Head, Cystic Fibrosis Service, Alfred Health Australia" (Vertex

Announces Reimbursement Agreement in Australia for TRIKAFTA

(Elexacaftor/Tezacaftor/Ivacaftor and Ivacaftor) for Patients with Cystic Fibrosis Ages 12 Years

and Older With at Least One F508del Mutation in the CFTR Gene, 2022).

On January 26, 2022, Vertex announced their fourth quarter 2021 and full year financial

results. In 2021, Vertex delivered exceptional financial performance, including 22% revenue

growth to $7.57 billion compared to 2020. Net product revenues in 2021 increased 10% to $5.29

billion in the U.S. and increased 66% to $2.29 billion outside the U.S., compared to 2020 (Vertex

Reports Fourth Quarter 2021 and Full Year Financial Results, 2022).

Each of these recent events shows growth and expansion which are attractive aspects to

what the company is looking for in a potential buyer. They have active research and development

as well as the financial needs to keep the studies going. They are constantly expanding, which is

an indication that employees of this organization will remain, and layoffs can be prevented.