Question
p53 binding to DNA can be inhibited by another protein, MDM2, MDM2 binds directly to p53 with high affinity to form a p53:MDM2 complex that
p53 binding to DNA can be inhibited by another protein, MDM2, MDM2 binds directly to p53 with high affinity to form a p53:MDM2 complex that cannot bind DNA.
(a) In many cancer cells, MDM2 is expressed at high levels. Explain how this would reduce the binding of p53 to DNA.
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Introduction to Chemical Engineering Thermodynamics
Authors: J. M. Smith, H. C. Van Ness, M. M. Abbott
7th edition
71247084, 978-0071247085
