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PA Pharmaceuticals have developed a process for the production 1 million kg of aspirin (acetyl salicylic acid) per year. The process is based on the

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PA Pharmaceuticals have developed a process for the production 1 million kg of aspirin (acetyl salicylic acid) per year. The process is based on the reaction between salicylic acid and 20% stoichiometric excess of acetic anhydride and 10% by wt concentrated sulphuric acid (based on the mass of salicylic acid). This reaction is exothermic (heat of reaction is 84kJ/mol ) and is carried out in a batch reactor operating in semi-batch mode. The plant runs 24 hours a day and is available for operation 8000 hours per year. The reaction is carried out at a temperature of 90C. Assume the reaction yield to be 95%. i.e. 95% of the limiting reactant salicylic acid is converted to product in the reactor. Batch reaction cycle is 5 hours. At the end of the reaction cycle the reactor contents are discharged to a crystalliser where the contents are cooled to 0 deg. cent. at a rate of 0.1deg. cent. per min. To avoid a delay before the next batch is started, a number of crystallisers are required. Other separation and purification processes required are: centrifugation (or filtration), including a washing cycle, and drying. These processes are assumed to take a total of 5 hours. The mother liquor from the centrifugation (or filtration) step is separated by distillation. Acetic anhydride is reused in the process and the acetic acid is recovered for resale. Waste waters are treated in a waste water treatment plant. Refer to the notes page for a number of assumptions and directions to assist with the assignment. The assignment is broken down into consecutive sections. Prepare a report on the following using a standard referenced report format

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