Part 1 chlorpromazine affinity

1 adrenoreceptor 1.9 x 10-8M M3 Muscarinic 7.1 x 10-8M

H1 Histamine 3.5 x 10-9M 5HT2 4.3 x 10-10M

Dopamine D2 2.1 x 10-9M Angiotensin II AT1> 1 x 10-6M

Explain what the KB value means for an antagonist (in general).

What does the number represent, and what does it tell you about the antagonist?

Analyse the data provided for chlorpromazine which receptor subtypes from the list above would most likely have chlorpromazine bound if the plasma concentration was 1 mM*