PBH 321 M5A1: Analytic epidemiology application - more designs, more decisions Introduction This week's activity will help to pull the last two modules together, to provide a more comprehensive view of analytic epidemiologic study designs. By the end of this activity you will be able to discern study design choices based on the description of a study, and calculate and interpret the correct measure of association for that study design. Instructions Before beginning this activity, read the module notes and the sections of your text, and view the required video. This activity will ask you to identify what study design was used based on a description, and then calculate and interpret the appropriate measure of association. Review the study in each section, and answer each question to the best of your knowledge. Make sure to save your worksheet to your computer before entering answers. After you have completed your worksheet, return to the course assignment and follow instructions there to upload and submit it. Scenario 1: Aspirin and Kidney Cancer A group of researchers were interested in studying the use of aspiring and the incidence of kidney cancer. They designed their study and enrolled 13,987 white, affluent, and well educated residents of a retirement community (9,621 women and 4,366 men). 3,490 men, and 6,021 women did not use aspirin upon enrollment. There were a total of 25 cases of kidney cancer that were reported after 6.5 years of follow up (15 among men, 10 among women). Among the males who developed kidney cancer, 9 used aspirin; of the females who developed kidney cancer, 4 used aspirin. 1. What type of study design was used? (1 pt) Place letter answer here: Click or tap here to enter text. a. b. c. d. e. Ecologic study Cross-sectional study Case-control study Cohort study Randomized control trial 2. Complete a 2x2 table for males with aspirin use as the exposure, and kidney cancer as the outcome (5 pts): Outcome status - Kidney Cancer Present Outcome status - Kidney Cancer Absent Total Exposure status - As- Click or tap here to en- Click or tap here to en- Click or tap here to enpirin Used (Present) ter text. ter text. ter text. Exposure status - No Click or tap here to en- Click or tap here to en- Click or tap here to enAspirin Used (Abter text. ter text. ter text. sent) Total Click or tap here to en- Click or tap here to en- Click or tap here to enter text. ter text. ter text. PBH 321 M5A1: Analytic epidemiology application - more designs, more decisions 3. What was the relative risk of kidney cancer associated with aspirin use among males (rounding to the nearest 100th as you calculate)? (5 pts) Place letter answer here: Click or tap here to enter text. a. b. c. d. 0.2 5.0 6.0 Odds ratio is the appropriate measure of association for this design 4. What is the best interpretation of the study results? (2 pts) Place letter answer here: Click or tap here to enter text. a. The risk of aspirin use is 5.0 times higher among males who get kidney cancer, than males who do not. b. The odds of kidney cancer among males who use aspirin is 6.0 times higher among those who use aspirin than among males who do not use aspirin. c. The risk of kidney cancer among males who use aspirin is 0.2 times that of those who do not use aspirin. d. The risk of kidney cancer among males who use aspirin is 5.0 times higher than those who do not use aspirin. Scenario 2: Effects of Tea A group of researchers are interested in the potential anti-carcinogenic effects of tea. Given new reports of increased incidence of breast cancer in their town, they wanted to determine if there was any association between breast cancer and tea consumption as the exposure. They enrolled 25 women with breast cancer, and 50 women without breast cancer for their study. 5. What type of study design was used? (1 pt.) Place letter answer here: Click or tap here to enter text. a. b. c. d. e. Ecologic study Cross-sectional study Case-control study Cohort study Randomized control trial 6. Ten women with breast cancer, and 25 without consumed green tea. Complete a 2x2 table for females with green tea consumption as the exposure, and breast cancer as the outcome (5 pts): Outcome status - Breast Cancer Present Outcome status - Total Breast Cancer Absent Exposure status - Tea Click or tap here to en- Click or tap here to en- Click or tap here to enConsumed (Present) ter text. ter text. ter text. Exposure status - No Click or tap here to en- Click or tap here to en- Click or tap here to enTea Consumed (Ab- ter text. ter text. ter text. sent) PBH 321 Total M5A1: Analytic epidemiology application - more designs, more decisions Click or tap here to en- Click or tap here to en- Click or tap here to enter text. ter text. ter text. PBH 321 M5A1: Analytic epidemiology application - more designs, more decisions 7. What was the relative risk of breast cancer associated with green tea consumption (rounding to the nearest 100th as you calculate)? (5 pts) Place letter answer here: Click or tap here to enter text. a. b. c. d. 0.8 0.6 1.3 Odds ratio is the appropriate measure of association for this design 8. What is the best interpretation of the study results? (2 pts) Place letter answer here: Click or tap here to enter text. a. The risk of green tea consumption is 1.3 times higher among women with breast cancer, than women without breast cancer. b. The odds of breast cancer among women who consumed green tea was 0.6 times that of women who did not consume green tea. c. The risk of breast cancer among those who consume green tea 0.8 times that of those who do not consume green tea. d. The odds of breast cancer among those who consume green tea 0.8 times that of those who do not consume green tea