Plasma samples from a patient were collected after an oral bolus dose of 10 benzodiazepine solution as follows: of mg a new Concentration (ng/mL) Time (hour) 0.25 2.85 0.50 5.43 0.75 7.75 1.00 9.84 2.00 16.20 4.00 22.15 6.00 23.01 10.00 19.09 14.00 13.90 7.97 20.00 From the above data: a. Determine the elimination constant of the drug. bDetermine k by feathering. Determine the equation that describes the plasma drug concentration of the new benzo- diazepine. 2. Assuming that the drug in Question 1 is 80% absorbed, find (a) the absorption constant, ka (b) the elimination half-life, t12; (c) the t, time of peak drug concentration; and (d) the volume of distribution of the patient. or max Plasma samples from a patient were collected after an oral bolus dose of 10 benzodiazepine solution as follows: of mg a new Concentration (ng/mL) Time (hour) 0.25 2.85 0.50 5.43 0.75 7.75 1.00 9.84 2.00 16.20 4.00 22.15 6.00 23.01 10.00 19.09 14.00 13.90 7.97 20.00 From the above data: a. Determine the elimination constant of the drug. bDetermine k by feathering. Determine the equation that describes the plasma drug concentration of the new benzo- diazepine. 2. Assuming that the drug in Question 1 is 80% absorbed, find (a) the absorption constant, ka (b) the elimination half-life, t12; (c) the t, time of peak drug concentration; and (d) the volume of distribution of the patient. or max