Answered step by step
Verified Expert Solution
Link Copied!

Question

1 Approved Answer

Please answer + code on Matlab... The file is written below hw6_data %The first column is time in days and the second one is measured

Please answer + code on Matlab... The file is written below

image text in transcribed

"hw6_data"

%The first column is time in days and the second one is measured virus concentration

data=[-10 131334 -9 130748 -8 130223 -7 132089 -6 134453 -5 133575 -4 132779 -3 132123 -2 131524 -1 130300 0 133230 1 133089 2 98668 3 73080 4 53579 5 39405 6 28333 7 19182 8 14888 9 12405 10 8043 11 6249 12 4939 13 2440 14 2003];

1. (computing) A simple model of HIV dynamics is dtdV=PcV, where P is virus production rate, V is virus concentration (per mL ), and c is the clearance rate. Suppose a protease inhibitor drug is given, resulting in production becoming 0 . (a) The text file ("hw6_data") on the website records how a patient's virus concentration changes with time. Time (measured in days) is scaled so that treatment begins on day 0 . Use this data to estimate c, assuming that once treatment starts, P=0. This can be done by plotting the natural log of virus concentration vs time after time 0 , and fitting a line through the resulting scatter plot. Make a plot of this scatter plot, and a line going through the post-treatment points. Side note: Since P does not instantly go to 0 when the inhibitor is given, this is actually a lower bound of c. As we saw in class, a better estimate (found by fitting data to a more accurate model) is c=3.1 per day. (b) Suppose that before treatment the virus production was in equilibrium. What was the production rate, P ? (This requires estimating V0, the steady state virus concentration, from the data.) (c) What is the total virus production per day (pre-treatment) if the person's fluid volume is estimated to be 15103mL ? Note: Before these calculations were done, it was thought that virus production during the latent period was small. This calculation changed how people thought of HIV dynamics

Step by Step Solution

There are 3 Steps involved in it

Step: 1

blur-text-image

Get Instant Access to Expert-Tailored Solutions

See step-by-step solutions with expert insights and AI powered tools for academic success

Step: 2

blur-text-image

Step: 3

blur-text-image

Ace Your Homework with AI

Get the answers you need in no time with our AI-driven, step-by-step assistance

Get Started

Recommended Textbook for

Harness The Power Of Big Data The IBM Big Data Platform

Authors: Paul Zikopoulos, David Corrigan James Giles Thomas Deutsch Krishnan Parasuraman Dirk DeRoos Paul Zikopoulos

1st Edition

0071808183, 9780071808187

More Books

Students also viewed these Databases questions

Question

10-7. How do proposal writers use an RFP? [LO-7]

Answered: 1 week ago