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Please answer it. Thank you. An ophthalmic suspension product containing the following ingredients formulated by a glass scientist and placed on stability; Formulation %w/w Drug(thermolabile)

Please answer it. Thank you.

An ophthalmic suspension product containing the following ingredients formulated by a glass scientist and placed on stability;

Formulation %w/w

Drug(thermolabile) 2.00

Sorbitan 0.50

Benzyl conium chloride 0.10

EDTA Na. 0.20

Sodium sulfate. 0.30

Citric acid buffer 0.25

Purified water q.s to 100.00

AVAILABLE DATA:

Drug powder- thermolabile

Drug particle size- o.50um

Density of drug-1.30g/cm3

The density of solvent: 0.90cm/3

The viscosity of the solvent: is 0.009 poise

porosity: is 0.75.

1. write stokes and modified stokes law equation for estimating the rate of sedimentation during stability testing?

2. Will stokes law be a good predictor for estimating the caking potential for this particular formulation if yes or no explain Y?

3. Calculate the (V) sedimentation rate from stokes law using the physical data provided?

4. During stability if this 30ml formulation is observed to be set at a rate of 0.5ml/month then after how many months this will have a sedimentation volume of 0.7?

5. What will be the appropriate method used in the sterilization of this type of suspension formulation?

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