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2 Which one of the below given occasions can not be counted among the reasons of risen interest on biomaterials? a) to replace of body part that has lost function b) correct abnormalities c) to change the apperaence cosmetically d) assist in healing 3) Which one of the below properties are not belong to biomaterials a) pharmacologically inert substance b) excreted fast c) combination of substances utilized for implantation d) to supplement or replace functions of living tissues or organs 2)-Blocompatibility, is "The ability of a material to perform with an appropriate host response in a specific application". The below givens can be counted among appropriate host responses EXCEPT. a) Osseointegration b) Resistance to blood clotting, c) Resistance to bacterial colonization, d) Uncomplicated healing 18) Biomaterials surface coatings are applied to improve the implant integration to body. Sort the adherences of different coating techniques to surfaces from poor to good adherence and also according to thickness. 19. The below given biomaterial characteristics may affect the overall in vitro/in vivo responses of the medical device EXCEPT a) Quantity and quality of material b) Degradation Products c) Physico-chemical properties of material d) Additives and contaminant, residues The focuses of biodegradation tests are listed below. Which one is not among these focusses? a) The amount of degradation during a given period of time b) The secretion pathway of the degradation products and leachables c) The nature of the degradation products, d) The origin of the degradation products (e.g., impurities, additives, corrosion products, bulk polymer) 21) Is the statement True or False? Chronic toxicity tests should be run during a period of 90 days for the test animals. 27 Sort the below given steps prior to in vivo tests of a biomaterial. Assurance of sterilized material preparation Appropriate computer simulation models Prerequisite material characterization tests - Pertinent in vitro models 23) What are the 3R rules in in vivo test? 26) n biomaterials design enginnering the surface properties effect the biological interactions (TRUE/FALSE) Chemotaxis Production of ECM Migration of the cells Composition of ECM Responsiveness to extracellular signaling 27) The following idealized data was obtained from tensile testing of steel. Answer the questions with the help of graph and given data set. 1000 900 800 Strain Stress (MPa) 0 0 700 0.0005 100 600 0001 200 0.0015 300 500 400 0.002 0.0025 500 400 0.003 509 300 0.005 544 200 0.01 625 0.02 756 100 0.03 845 0.04 802 0.05 897 0 0.02 0.04 0.06 0.08 0.1 0.06 860 0.07 782 Strain 0.08 062 a. Determine the yield strength (o,) and ultimate tensile strength of this materials. Mention the estimated value with the aid of graph. b. Provide the definition of resilience and calculate the modulus of resilience by using the the given data set for calculation? 28) The principal functions of the ECM are; EXCEPT a) Mechanical support for cell anchorage b) Cell proliferation c) Regulates and determine cells dynamic behavior d) Scaffolding for orderly tissue renewal 29) Fill in the blanks Cells adjacent to one another frequently communicate through. Other forms of cell-cell communication through...... www.. In extracellular signaling ligand-receptor interaction induce; Cell-to-cell communication by extracellular signaling usually involves six steps, sort the below given steps according to happening order; Removal of the signal, which usually terminates the cellular response - degradation of ligand----- A change in cellular metabolism, function, or development CELLULAR RESPONSE triggered by the receptor-ligand complex-specific to the ligand-receptor complex------- Release of the signaling molecule by the signaling cell Transport of the signal to the target cell--- Synthesis of the signaling molecule by the signaling cell------- Detection of the signal by a specific receptor protein (receptor-ligand specificity)----- Stress (MPa) 0