Preclinical development is the last set of activities to prepare for filing an Investigational New Drug Application with the FDA. Which of the following are NOT central activities at this stage? Group of answer choices Comprehensive review of the Structure-Activity Relationships (SAR) within the series of analogs which generated the Candidate compound, including SAR of potency at target, selectivity, and biophysical properties. Detailed plan for execution of the Phase I trial, including background and qualifications of the investigators and organizations who will conduct the studies. Execution of safety/toxicology studies under "Good Laboratory Practices" (GLP), meaning rigorously documented and witnessed. Thorough documentation of the methods of preparing the Candidate compound and rigorous characterization of the Candidate compound's purity, including identification of impurities