Predict the consequences of the following: Two homologous chromosomes have gene G. P = Promoter; X = Area of recombination; C = Coding region. A woman has the following two alleles on homologous X chromosomes. Chromosome X has the silenced copy because the promoter (P2) was irreversibly methylated. P1 and C1 are active; C2 has a mutation that makes the gene inactive and lethal in males. A crossing over happens at R with a frequency of 23%. What may be the reason that this is lethal in males? For the woman's male offspring, give the probability of healthy vs unhealthy and show the chromosomes in each of the cases. P1 has a TATAAA box and is a constitutive promoter in a euchromatic region. P2 has a CpG island in a facultative heterochromatic region. For both genes, any defect is haplosufficient (i.e., a defect in one chromosome is sufficient to cause harm). Which type of rearrangement do you see represented to the left ? Give the designation of the condition in a female with no other abnormalities. What changes in gene structure did it lead to? What is the probability of inheriting both abnormal chromosomes? For a child who inherits both these chromosomes, what may the consequences be? A child inherits a normal chr 5 but an abnormal chr 1. What may the consequences be? Large Corporation has collected the following information after its first year of sales. Sales were $2, 250,000 on 90,000 units; selling expenses $250,000 (40% variable and 60% fixed); direct materials $1, 131, 400; direct labor $230,000; administrate expenses $270,000 (20% variable and 80% fixed); and manufacturing overhead $378,000 (70% variable and 30% fixed). Top management has asked you to do a CVP analyses so that it can make plans for the coming year. It has projected that unit sales will increase by 10% next year. Compute the contribution margin for the current year and the projected year, and the fixed costs for the current year. (Assume that fixed costs will remain the same in the projected year.) Compute the break-even point in units and sales dollars for the first year. (Round contribution margin ratio to 2 decimal places e.g. 0.15 and final answers to 0 decimal places, e.g. 2, 510.) The company has a target net income of $190,000. What is the required sales in dollars for the company to lived its target? If the company meets its target net income number, by what percentage could its sales fall before it is operating at a That is, what is its margin of safety ratio? (Round answer to 1 decimal place, eg. 10.5.) The company is considering a purchase of equipment that would reduce its direct later costs by $110,000 and would change its manufacturing overlie ad costs to 30% variable and 70% fixed (assume total manufacturing overhead cost is $378,000, as above). It is also considering switching to a pure commission basis for its sales staff. This would charge selling expellees to 90% variable and 10% fixed (assume total selling expense is $250,000, as above). Compute the contribution margin and the contribution margin ratio, and recompute the break-even point in sales dollars. (Round contribution margin ratio to 2 decimal places e.g. 25.35 and all other answers to theta decimal places, e.g. 2, 520. Use the current year numbers for calculations.)
