PROBABILITY AND STATISTICS

__________ data is what is translated to digital format so it can be stored in a computer

The aminoglycosides (AG's) are positively-charged molecules which attach to the OM which is negatively charged leading to formation of large pores, and thus allow antibiotic penetration inside the bacterium. The main target of action is bacterial ribosome; to enter, there it must pass through cytoplasmic membrane requiring energy dependent active bacterial transport mechanism, which requires oxygen and an active proton motive force. For these reasons, AG work in aerobic conditions and have poor activity against anaerobic bacteria. These AG have synergism with those antibiotics, which inhibit cell wall synthesis (such as -lactam and glycopeptides) as it allows greater penetration of AG within the cell and at low dosages. AG's interact with the 16S r-RNA of the 30S subunit near the A site through hydrogen bonds. They cause misreading and premature termination of translation of mRNA.

1.interconnect the Klinefelter to the example of trisomy

2.how does the disruption of the Gene balancerender the Aneuploidy deleterious

3. Turner's syndrome is a result of?elaborate

4.calculate the 12 numbers generated by the organism has 14 chromosomes in nullisomy

5.justify; In aneuploidy the entire set of chromosome is not involved in duplication of deletion.

6.elaborate on the coding factor of the Cdc-20?

7. The inactivation of M-Cdk is through the Cdc20-APC activity, what activates Cdc-20-APC?

8.P53 requires ________________for its activity.explain

9.among the daughter cels,explain the Hydroxyurea prevention ofDNA replication

10.explain the activation process as attained by theCdc25