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Problem 4. The antitumor agent bizelesin was found to form interstrand crosslinks at the underlined positions within the double-stranded sequence GTACTAAGT in the p53
Problem 4. The antitumor agent bizelesin was found to form interstrand crosslinks at the underlined positions within the double-stranded sequence GTACTAAGT in the p53 gene. Suggest a plausible arrow-pushing mechanism for the formation of DNA crosslinks and include the structure of the final crosslinked adenine bases. (hint: a strained ring in involved as the electrophile) CI CI bizelesin HN NH N.
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Cost Management Measuring Monitoring And Motivating Performance
Authors: Leslie G. Eldenburg, Susan K. Wolcott
2nd Edition
978-0-470-7694, 0470769424, 978-0470769423
