Question 111: In cases of hypertensive heart failure, should furosemide or amlodipine be taken to lower blood pressure?Which is the most efficient, if so? In what ways does diabetes contribute to endothelial dysfunction?How are ACE inhibitors involved in the kinin-kallikrein system?What are the mechanisms by which endothelial dysfunction is brought on by a decrease in nitric oxide levels? Question 113: Is it possible to administer sublingual nifedipine to a patient who has accelerated or malignant hypertension?It appears to be a contentious issue, with some in favor and others opposed. Question 114: Even in the presence of normotensive conditions, is the retinopathy the only factor that contributes to the diagnosis of malignant hypertension?Parenteral administration of labetalol is an option for treating malignant hypertension.In addition to this medication, what other more easily accessible preparations, other than sodium nitroprusside, are suggested?Pakistan does not offer labetalol for parents! Question 115: Typically, specific prophylaxis with 5000 units of low-dose heparin administered subcutaneously every 8 to 12 hours until the patient is ambulatory is given to patients with a medium risk of DVT and pulmonary embolism.Is the first dose of 13 Cardiovascular disease 132 given immediately following, for example, extensive surgery for varicose veins in the small and great saphenous veins? According to K&C 7e, page 809, question 116, "Anticoagulants are not necessary, since embolism does not occur from superficial thrombophlebitis."Why? Question 117: Can enoxaparin be used to prevent deep vein thrombosis (DVT) immediately following surgery and in cases of cerebral hemorrhage?In either scenario, wouldn't it raise the risk of hemorrhage? Question 118: Can tingling and numbness over the earlobe and the lower face that is adjacent to it be caused by external jugular vein thrombosis? Question 119: How long must a patient be bedridden in order to be eligible for low-molecular-weight heparin (LMWH) as a preventative measure against deep vein thrombosis? Question 120: Is an inferior vena cava filter an alternative treatment for a patient on lifelong warfarin anticoagulation who has a history of recurrent deep vein thrombosis?