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QUESTION 2A Calculate AG in KJ/mol for this ATP coupled reaction using the data table provided; Phosphocreatine + ADP ----> Creatine + ATP TABLE 14-3

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QUESTION 2A Calculate AG in KJ/mol for this ATP coupled reaction using the data table provided; Phosphocreatine + ADP ----> Creatine + ATP TABLE 14-3 Standard Free Energies of Phosphate Hydrolysis of Some Compounds of Biological Interest Compound AG' (kJ. mol-) Phosphoenolpyruvate -61.9 1,3-Bisphosphoglycerate -49.4 ATP ( AMP + PP) -45.6 Acetyl phosphate -43.1 Phosphocreatine -43.1 ATP (-- ADP + P) -30.5 Glucose-1-phosphate -20.9 -19.2 Fructose-6-phosphate -13.8 Glucose-6-phosphate -13.8 Glycerol-3-phosphate -9.2 Source: Mostly from Jencks, W.P. in Fasman, G.D. (Ed.), Handbook of Biochemistry and Molecular Biology (3rd ed.). Physical and Chemical Data, Vol. I. pp. 296-304, CRC Press (1976). PP QUESTION 2B Calculate the AG in KJ/mol for the reaction of; Phosphocreatine + ADP ----> Creatine + ATP at 25C, as occurs in the cytosol of a neuron, with phosphocreatine at 4.7mM, creatine at 1.OmM, ADP at 0.73mM and ATP at 2.6MM

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