Question 4 0.5 out of 1 points You have read how bacteria utilize D-alanine in making cell walls and how this is a target for antibiotics. Humans have also developed specialized roles for some D- % amino acids. D-serine is synthesized by the enzyme serine racemase and it is degraded by D-amino acid oxidase. Both of these enzymes are present in the brain where D-serine binds to and enhances the activity of NMDA receptors. Reduced activity of NMDA receptors is associated with schizophrenia. Drug companies and researchers are testing ways to increase NMDA receptor activity to reverse the effects of this serious mental illness. The reaction catalyzed by serine racemase is shown below. Below that is an incomplete Fischer projection of serine where the positions of the a-amine and a-carboxyl groups are replaced by an A and B. Complete the table below to indicate the appropriate positions of the missing groups and the stereochemical designations of the left and right structures of the serine-racemase catalyzed reaction. *HEN CO2 -CO2 *H3N Serine racemose HO HO OH CH2 A-C-B H -COO" position -NH3 position isomer left structure [S1] [S2] [53] right structure [54] [S5] [56] Selected You have read how bacteria utilize D-alanine in making cell walls and how this is a target for antibiotics. Humans have also developed specialized roles for Answer: some D-amino acids. D-serine is synthesized by the enzyme serine racemase and it is degraded by D-amino acid oxidase. Both of these enzymes are present in the brain where D-serine binds to and enhances the activity of NMDA receptors. Reduced activity of NMDA receptors is associated with schizophrenia. Drug companies and researchers are testing ways to increase NMDA receptor activity to reverse the effects of this serious mental illness. The reaction catalyzed by serine racemase is shown below. Below that is an incomplete Fischer projection of serine where the positions of the a-amine and a-carboxyl groups are replaced by an A and B. Complete the table below to indicate the appropriate positions of the missing groups and the stereochemical designations of the left and right structures of the serine-racemase catalyzed reaction. Selected You have read how bacteria utilize D-alanine in making cell walls and how this is a target for antibiotics. Humans have also developed specialized roles for some c-amino acids. D-serine is Answer: synthesized by the enzyme serine racemase and it is degraded by D-amino acid oxidase. Both of these enzymes are present in the brain where D-serine binds to and enhances the activity of NMDA receptors. Reduced activity of NMDA receptors is associated with schizophrenia. Drug companies and researchers are testing ways to increase NMDA receptor activity to reverse the effects of this serious mental illness. The reaction catalyzed by serine racemase is shown below. Below that is an incomplete Fischer projection of serine where the positions of the c-amine and o-carboxyl groups are replaced by an A and B. Complete the table below to indicate the appropriate positions of the missing groups and the stereochemical designations of the left and right structures of the serine- racemase catalyzed reaction. +H3N co, *H3N CO2 Serine racemose 11 HO HO OH CH, A-C-B . -COO position -NHposition isomer left structure A L-Ser right structure A A D-Ser Response This question requires you to use spatial relationships. Remember - dashed triangles in stereochemical structures are bonds that project behind the page. Solid bonds project in front of Feedback: the page. Use the "amino acid chiraity" resource in blackboard to determine group priorities. First, identify the Land D-enantiomers of the stereochemical structures. This is most easily done with the structure on the right since the H is behind the alpha carbon. Determine the priority of the groups as shown, Clockwise or counterclockwise? Now look at the Fischer projection. The side chain and H groups are given. Place the NH3 and Coo groups so that the rotation is the same. The left structure is identical except the Hand NH3 positions have been switched. This enantiomer will have the A and B groups of the Fischer projection reversed. Question 4 0.5 out of 1 points You have read how bacteria utilize D-alanine in making cell walls and how this is a target for antibiotics. Humans have also developed specialized roles for some D- % amino acids. D-serine is synthesized by the enzyme serine racemase and it is degraded by D-amino acid oxidase. Both of these enzymes are present in the brain where D-serine binds to and enhances the activity of NMDA receptors. Reduced activity of NMDA receptors is associated with schizophrenia. Drug companies and researchers are testing ways to increase NMDA receptor activity to reverse the effects of this serious mental illness. The reaction catalyzed by serine racemase is shown below. Below that is an incomplete Fischer projection of serine where the positions of the a-amine and a-carboxyl groups are replaced by an A and B. Complete the table below to indicate the appropriate positions of the missing groups and the stereochemical designations of the left and right structures of the serine-racemase catalyzed reaction. *HEN CO2 -CO2 *H3N Serine racemose HO HO OH CH2 A-C-B H -COO" position -NH3 position isomer left structure [S1] [S2] [53] right structure [54] [S5] [56] Selected You have read how bacteria utilize D-alanine in making cell walls and how this is a target for antibiotics. Humans have also developed specialized roles for Answer: some D-amino acids. D-serine is synthesized by the enzyme serine racemase and it is degraded by D-amino acid oxidase. Both of these enzymes are present in the brain where D-serine binds to and enhances the activity of NMDA receptors. Reduced activity of NMDA receptors is associated with schizophrenia. Drug companies and researchers are testing ways to increase NMDA receptor activity to reverse the effects of this serious mental illness. The reaction catalyzed by serine racemase is shown below. Below that is an incomplete Fischer projection of serine where the positions of the a-amine and a-carboxyl groups are replaced by an A and B. Complete the table below to indicate the appropriate positions of the missing groups and the stereochemical designations of the left and right structures of the serine-racemase catalyzed reaction. Selected You have read how bacteria utilize D-alanine in making cell walls and how this is a target for antibiotics. Humans have also developed specialized roles for some c-amino acids. D-serine is Answer: synthesized by the enzyme serine racemase and it is degraded by D-amino acid oxidase. Both of these enzymes are present in the brain where D-serine binds to and enhances the activity of NMDA receptors. Reduced activity of NMDA receptors is associated with schizophrenia. Drug companies and researchers are testing ways to increase NMDA receptor activity to reverse the effects of this serious mental illness. The reaction catalyzed by serine racemase is shown below. Below that is an incomplete Fischer projection of serine where the positions of the c-amine and o-carboxyl groups are replaced by an A and B. Complete the table below to indicate the appropriate positions of the missing groups and the stereochemical designations of the left and right structures of the serine- racemase catalyzed reaction. +H3N co, *H3N CO2 Serine racemose 11 HO HO OH CH, A-C-B . -COO position -NHposition isomer left structure A L-Ser right structure A A D-Ser Response This question requires you to use spatial relationships. Remember - dashed triangles in stereochemical structures are bonds that project behind the page. Solid bonds project in front of Feedback: the page. Use the "amino acid chiraity" resource in blackboard to determine group priorities. First, identify the Land D-enantiomers of the stereochemical structures. This is most easily done with the structure on the right since the H is behind the alpha carbon. Determine the priority of the groups as shown, Clockwise or counterclockwise? Now look at the Fischer projection. The side chain and H groups are given. Place the NH3 and Coo groups so that the rotation is the same. The left structure is identical except the Hand NH3 positions have been switched. This enantiomer will have the A and B groups of the Fischer projection reversed