Question 5 [10 marks] a) In a normal, full-term, healthy newborn what is the primary site/organ system for production of blood cells (hematopoiesis)? [2 mark] b) The Bohr effect is a physiological phenomenon first described in 1904 by the Danish physiologist Christian Bohr, stating that hemoglobin's oxygen binding affinity is inversely related both to acidity [H+] and to the concentration of carbon dioxide (CO2). This manifests as a right-ward shift in the Oxygen-Hemoglobin Dissociation Curve described in Oxygen Transport and yields enhanced unloading of oxygen by hemoglobin. Complete the following table by indicating if the corresponding shift of the curve is [LEFT] or [RIGHT). [4 marks] Control factors Change Shift of curve ? Temperature 1 ? t ? 2,3-BPG ? 1 1 1 ? PCO2 ? f ? Acidity [H*] ? c) Name two (2) nutritional factor deficiencies that are sometimes associated with MACROCYTIC anemia. Also provide 2 biochemistry tests that identifies a true metabolic deficiency of these nutritional factors. (4 marks)