Questions 1 (need to use R to generate):

a.Define bioavailability

b.What is the more commonly used term for incidence density and what is the unit of this measure?

c. Determine the baseline of betacarotene by calculating the aver of the first and second baseline determinations for carotene.

d. Suppose we regard a preparation as being bioavailable for a subject at the first week when level of plasma carotene increases by 50% from the baseline level (based on your answer above). Calculate the ratio between plasma level and baseline for each subject at 6 , 8 ,10 and 12 weeks.

e.What proportion of subjects will then not have 50% bioavailability at 10 weeks? (2)