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Questions 3 and 4 please thank you. Figure 3. Suzuki Reaction Using Unknown Reagents cat. Pd(OAc)2 cat. PPh3 Br B(OH)2 1M Na2CO3(aq) R' n-Propanol, N2
Questions 3 and 4 please thank you.
Figure 3. Suzuki Reaction Using Unknown Reagents cat. Pd(OAc)2 cat. PPh3 Br B(OH)2 1M Na2CO3(aq) R' n-Propanol, N2 110C, 1h R R' Prelab Questions 1) Based on the Material Safety Data Sheets (MSDS) for the compounds, which of the compounds in this experiment is the most hazardous, and why? 2) Draw the reaction scheme and finish filling in the reagent table in your lab notebook. Remember, you do not know the identity of your bromide or boronic acid yet, so you cannot fill in all of the information for these two entries or the Mol.-eq. until after you identify the two starting materials. Name Formula Mol.-eq. Mw mmol Density/Conc. Amount (Aryl bromide) 600 mg (Boronic acid) 600 mg Palladium(II) Acetate Triphenylphosphine Na,CO31A) n-Propanol 3.6 mg 12.8 mg 2.0 mL 4.0 mL 1M 3) What principles of green chemistry are embodied by the Suzuki Cross Coupling Reaction (for each briefly describe why)? 4) Propose how the overall sustainability of this specific transformation could be improved (HINT: What is required of both substrates before you perform the reaction?)Step by Step Solution
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