re: 3101 introduction to figidemi Randomized Controlled Trial Problem (10 pts. each) Background. Recent interest has emerged in the potential therapeutic benefits of cannabidiol (pronounced "can-a-bid- EYE-ul") (CBD), a compound derived from the cannabis plant. Case reports suggest that CBD may benefit patients who suffer from epileptic seizures, but without the psychoactive effects of other cannabis-derived compounds. To test the potential therapeutic effects of CBD, investigators conducted an RCT to examine whether CBD reduced the frequency of epileptic seizures. They enrolled a total of 563 adult patients with severe epilepsy; 280 were randomized to take CBD and 283 took their usual epilepsy medication. The outcome of interest was whether participants experienced an epileptic seizure during the 6-month trial period. experienced a seizure. Among participants randomized to CBD, 21 experienced a seizure. Among participants taking their usual medication, 61 NOTE: TAU = treatment as usual To answer questions 33-35 you will find it helpful to construct a 2x2 table showing the above results, though you will not be graded on the table itself. IBC NO CBC 29. Calculate the correct measure of association to examine the relationship between CBD and epileptic seizures. A. OR = 0.35 LB. OR = 0.54 C. RR = 0.54 D. RR = 0.35 30. What is the interpretation for the finding in the previous question? A. The risk of seizures among patients with epilepsy who took CBD was 65% lower than the risk among patients who did not take CBD The odds of seizures among patients with epilepsy who took CBD was 65% lower than the odds among patients who did not take CBD C. The risk of seizures among patients with epilepsy who took CBD was 54% lower than the risk among patients who did not take CBD L D. The odds of seizures among patients with epilepsy who took CBD was 54% lower than the odds among patients who did not take CBD 31. What recommendation might you make about CBD based on this result? A. Patients with seizures may want to consider TAU to see if it reduces the frequency of seizures B. Patients with seizures may want to consider CBD to see if it reduces the frequency of seizures. C. Patients with seizures should not try TAU to see of it reduces the frequency of seizures D. Patients with CBD should not try CBD to see of it reduces the frequency of seizures Screening for Disease (10 pts. each) Background. Healthcare workers need to be screened for diseases such as tuberculosis before they can work in clin settings. Assume you have a population of 500 hospital workers who are known to have tuberculosis (TB), which been confirmed by a diagnostic chest X-ray. You have another group of 500 hospital workers who also received ch V2 - Page 7 of 9