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regarding https://www.nejm.org/doi/pdf/10.1056/NEJMoa2115869 What are the researchers aiming to figure out or what is the research question? What type of sampling method did they use to

regarding https://www.nejm.org/doi/pdf/10.1056/NEJMoa2115869

What are the researchers aiming to figure out or what is the research question?

What type of sampling method did they use to conduct this study

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