relative bioavailability for po vs ip, Fpo/Fip (3 points)

Chloroform is a potentially toxic chemical that is a common environmental contaminant due to its frequent use in industrial processes and subsequent discharge in industrial waste. Chloroform is also produced in chlorinated drinking water and in chlorinated swimming pools, so that chloroform exposure occurs often through ingestion and dermal exposure. The following chloroform data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration. 10 mg/kg bolus iv 500 mg/kg po or ip Time (hr) 0.083 0.50 1.0 2.0 3.0 Civ (mg/L) 2.679 1.988 1.359 0.730 0.401 Time (hr) 0.00 0.25 0.50 1.0 2.0 3.0 4.0 6.0 Cro (mg/L) 0.00 7.87 11.19 15.07 11.64 7.32 4.63 1.79 Cip (mg/L) 0.00 12.73 18.98 24.32 20.02 12.02 7.27 2.53