SCH3U1 Culminating Performance Task: Titration of Aspirin Lab Knowledge: /10 Thinking: /15 Communication: /10 Application: 10 Total: /45 The Task You will be watching the video provided for the Titration of Aspirin done by students just like you, as well as using laboratory data provided by the teacher to complete a formal lab report for the experiment. This lab report will assess your knowledge of the major course concepts, as well as your skills in research, communication and problem solving. Video: https://youtu.be/PTH7xOKY Co Background Information A tablet of aspirin contains the active ingredient Acetylsalicylic acid (ASA, H2CH.04) plus binders which together form the tablet. ASA is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. It has also an antiplatelet ("blood-thinning") effect and is used in long-term low-doses to prevent heart attacks and cancer. Introduction 15 KI This section should be about 6-10 lines long. Paragraph structure must be used. The initial paragraph should state the purpose of your experiment and include the basic theory (knowledge) needed in order to understand the experiment. Here are some questions you should answer within your introduction paragraph; Define an acid versus a base Is ASA an ionic or covalent compound? How about NaOH? How do you know? What type of reaction is happening during a titration? Explain the general reaction. What is the purpose of the phenolphthalein? What is the purpose of a titration? Purpose What is the mass of the active ingredient, Acetylsalicylic acid (ASA) in a commercial Aspirin tablet? Materials & Set-up Diagram [3C) Based on the video, create a list of equipment and chemicals which were used for the experiment. Draw and label a set-up diagram for the titration analysis. Procedure [50] Based on the video, write a procedure for the titration lab. Recall that a procedure must be written in past-tense, passive voice and contain numbered steps with specific instructions. Observations Qualitative Observations:[2 C) Table 1: Record the physical properties of the acid (solid) and the base before and after the titration. Use a data table with an appropriate title. Quantitative Observations: [Provided here by teacher] Table 2: Volume of NaOH (0.100M) used to titrate the ASA within a sample of Aspirin Total Volume Used (mL) Trial 1 2 3 Initial Volume (mL) 49.80 41.95 34.17 Final Volume (ml.) 41.95 34.17 26.52 Analysis and Discussion 1. Provide a theoretical explanation for the observation that C.H.0 2-ion (salicylate) is more soluble in water than the H2CH604 (ASA) molecule. [2K] 2. Based on the video, what was the final reading on the burette at the end of the first trial? Don't forget significant digits! [16] 3. Examine the photo of the flask....is the solution at its equivalence point? Explain? [2K] 4. Calculate the volume of NaOH(aq) used in mL and then convert to L. Show work. [2 T] 5. Write out the balanced chemical equation for the reaction between ASA and sodium hydroxide. Don't forget to include the states of matter for each compound in the reaction. [2T) 6. Stoichiometrically calculate the mass of the ASA in grams) in the sample of the tablet using the data provided to you in the observations section. Show all your work. [4T] 7. Assume the sample of aspirin used in the lab had a mass of 0.10g and the mass of a whole tablet is 0.39g, use a mass ratio to calculate the mass of ASA in one tablet. Show all work. [2 T] 8. Determine the percent composition by mass (%w/w) of ASA in one tablet. [2 T] 9. The accepted value of ASA's mass in one tablet is 0.325 g. Determine the percent error for the experiment. Show work. [2 T] 10. What is the purpose of the ethanol in the titration lab video? [17] 11. Suggest TWO important reasons why sources of error) the titrated volume of NaOH(aq) and therefore the calculated mass of ASA in one tablet may be inaccurate. (cause and effect) [4A] Cause Effect 12. The active ingredient in Tums tablets is aluminum hydroxide (Al(OH)3), if you were asked to find the mass of the aluminum hydroxide in the tums tablet, describe TWO changes that MUST be made in the lab you performed today. Write out a possible neutralization reaction that may occur during your titration of a tums tablet. [3] 13. Research and briefly summarize ONE real world example where the analytical technique of titration is used. (3A] SCH3U1 Culminating Performance Task: Titration of Aspirin Lab Knowledge: /10 Thinking: /15 Communication: /10 Application: 10 Total: /45 The Task You will be watching the video provided for the Titration of Aspirin done by students just like you, as well as using laboratory data provided by the teacher to complete a formal lab report for the experiment. This lab report will assess your knowledge of the major course concepts, as well as your skills in research, communication and problem solving. Video: https://youtu.be/PTH7xOKY Co Background Information A tablet of aspirin contains the active ingredient Acetylsalicylic acid (ASA, H2CH.04) plus binders which together form the tablet. ASA is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. It has also an antiplatelet ("blood-thinning") effect and is used in long-term low-doses to prevent heart attacks and cancer. Introduction 15 KI This section should be about 6-10 lines long. Paragraph structure must be used. The initial paragraph should state the purpose of your experiment and include the basic theory (knowledge) needed in order to understand the experiment. Here are some questions you should answer within your introduction paragraph; Define an acid versus a base Is ASA an ionic or covalent compound? How about NaOH? How do you know? What type of reaction is happening during a titration? Explain the general reaction. What is the purpose of the phenolphthalein? What is the purpose of a titration? Purpose What is the mass of the active ingredient, Acetylsalicylic acid (ASA) in a commercial Aspirin tablet? Materials & Set-up Diagram [3C) Based on the video, create a list of equipment and chemicals which were used for the experiment. Draw and label a set-up diagram for the titration analysis. Procedure [50] Based on the video, write a procedure for the titration lab. Recall that a procedure must be written in past-tense, passive voice and contain numbered steps with specific instructions. Observations Qualitative Observations:[2 C) Table 1: Record the physical properties of the acid (solid) and the base before and after the titration. Use a data table with an appropriate title. Quantitative Observations: [Provided here by teacher] Table 2: Volume of NaOH (0.100M) used to titrate the ASA within a sample of Aspirin Total Volume Used (mL) Trial 1 2 3 Initial Volume (mL) 49.80 41.95 34.17 Final Volume (ml.) 41.95 34.17 26.52 Analysis and Discussion 1. Provide a theoretical explanation for the observation that C.H.0 2-ion (salicylate) is more soluble in water than the H2CH604 (ASA) molecule. [2K] 2. Based on the video, what was the final reading on the burette at the end of the first trial? Don't forget significant digits! [16] 3. Examine the photo of the flask....is the solution at its equivalence point? Explain? [2K] 4. Calculate the volume of NaOH(aq) used in mL and then convert to L. Show work. [2 T] 5. Write out the balanced chemical equation for the reaction between ASA and sodium hydroxide. Don't forget to include the states of matter for each compound in the reaction. [2T) 6. Stoichiometrically calculate the mass of the ASA in grams) in the sample of the tablet using the data provided to you in the observations section. Show all your work. [4T] 7. Assume the sample of aspirin used in the lab had a mass of 0.10g and the mass of a whole tablet is 0.39g, use a mass ratio to calculate the mass of ASA in one tablet. Show all work. [2 T] 8. Determine the percent composition by mass (%w/w) of ASA in one tablet. [2 T] 9. The accepted value of ASA's mass in one tablet is 0.325 g. Determine the percent error for the experiment. Show work. [2 T] 10. What is the purpose of the ethanol in the titration lab video? [17] 11. Suggest TWO important reasons why sources of error) the titrated volume of NaOH(aq) and therefore the calculated mass of ASA in one tablet may be inaccurate. (cause and effect) [4A] Cause Effect 12. The active ingredient in Tums tablets is aluminum hydroxide (Al(OH)3), if you were asked to find the mass of the aluminum hydroxide in the tums tablet, describe TWO changes that MUST be made in the lab you performed today. Write out a possible neutralization reaction that may occur during your titration of a tums tablet. [3] 13. Research and briefly summarize ONE real world example where the analytical technique of titration is used. (3A]