Answered step by step
Verified Expert Solution
Question
1 Approved Answer
Show the COMPLETE MECHANISM for every compound (249 to 250, etc). Explain each process briefly NO2 NO2 OH HN NH NO (Boc),0, DMAP, DCM t-BuOH,
Show the COMPLETE MECHANISM for every compound (249 to 250, etc). Explain each process briefly
NO2 NO2 OH HN NH NO (Boc),0, DMAP, DCM t-BuOH, rt, 54% NO2 CHZI, K2CO3 MeCN, rt, 80% 251 DMF, rt, 75% F H 249 250 252 253 H OCF3 NH2 Pd/C, MOH H2, rt, 96% TFAA, TEA DCM, rt, 57% TFA, DCM N2, rt, 84% 255 TFA, NH_BH(OAc)3 N2, DCM, rt, 78% 254 256 257 NH2 OH COCF3 H F K2CO3, MeOH H20, N2, rt, 71% H 259 Fzcoc HN HN F 1. (COCI), DCM DMF, N2, rt 2. 259, DIPEA THF, N2, rt 57% for 2 steps 258 260 Entrectinib (XXVII)Step by Step Solution
There are 3 Steps involved in it
Step: 1
Get Instant Access to Expert-Tailored Solutions
See step-by-step solutions with expert insights and AI powered tools for academic success
Step: 2
Step: 3
Ace Your Homework with AI
Get the answers you need in no time with our AI-driven, step-by-step assistance
Get Started