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Show the COMPLETE MECHANISM for every compound (249 to 250, etc). Explain each process briefly NO2 NO2 OH HN NH NO (Boc),0, DMAP, DCM t-BuOH,

Show the COMPLETE MECHANISM for every compound (249 to 250, etc). Explain each process briefly

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NO2 NO2 OH HN NH NO (Boc),0, DMAP, DCM t-BuOH, rt, 54% NO2 CHZI, K2CO3 MeCN, rt, 80% 251 DMF, rt, 75% F H 249 250 252 253 H OCF3 NH2 Pd/C, MOH H2, rt, 96% TFAA, TEA DCM, rt, 57% TFA, DCM N2, rt, 84% 255 TFA, NH_BH(OAc)3 N2, DCM, rt, 78% 254 256 257 NH2 OH COCF3 H F K2CO3, MeOH H20, N2, rt, 71% H 259 Fzcoc HN HN F 1. (COCI), DCM DMF, N2, rt 2. 259, DIPEA THF, N2, rt 57% for 2 steps 258 260 Entrectinib (XXVII)

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