sign observed expected positive 13 8 negative 3 8 zero 1 1 all 17 17 One-sided tests: Ho: median of baseSBP Ha - - median of baseSBP Pr (#positive >= 13) Binomial (n = one SBP = 0 vs. one SBP > 0 = 16, x = 13, p = 0.5) Ho: median of baseSBP Ha median of baseSBP Pr (#negative >= 3) Binomial (n Two-sided test: = - - = one SBP = 0 vs. oneSBP < 0 16, x = 3, p = 0.5) Ho: median of baseSBP median of baseSBP Ha - - one SBP = 0 vs. one SBP != 0 = 0.0106 = 0.9979 Pr (#positive >= 13 or #23negative >= 13) min (1, 2*Binomial (n = = 16, x = 13, p = 0.5)) = 0.0213 Signed rank test Paired t test Two sample t test with unequal variances Sign test