Question
Solve; Questions to guide your note-taking: What did the Human Genome Project hope to accomplish? Was it successful? How does the genome of humans compare
Solve;
Questions to guide your note-taking:
What did the Human Genome Project hope to accomplish? Was it successful?
How does the genome of humans compare to that of plants? What does this suggest?
What is the similarity in the cause of Angelman's Syndrome and Prader-Willi Syndrome? What determines whether a child will get one or the other?
Given that a gene sequence is
Describe, what is the role of a tag or imprint?
Describe the two strains of "Agouti mice." What is different about them physically? Are they genetically different, or are they identical twins?
In lean agouti mice, the agouti gene is always ______. In obese agouti mice, the agouti gene is always _______. (ON or OFF)
The chemical tag that turns off the agouti gene is what type of molecule? ____________
What does it bind to? _______________
Other chemical tags control gene expression by binding to ___________________________.
Define epigenome and epigenetics.
What do cells of the skin, teeth, and organs have in common? What makes the cells different?
How did researchers turn off the overactive agouti gene in mice? [ VERY IMPORTANT!] What was the result?
Implications for fetal development?
Are the DNA sequences of identical twins exactly the same throughout their lives? _________ What about their DNA tags? _________
Are lifestyle and environment are more likely to affect the genome or the epigenome?
Rat study: What was different about the pups that were neglected by their mothers compared to those that were nurtured?
What happened when the pups were switched at birth? Why did the researchers test this?
Stress hormone levels were higher in which pups? Why? [THIS IS IMPORTANT!]
Thoughts on this finding? Nature versus nurture?
How did the researchers modify the epigenome of the rats? What was the result?
Are epigenetic marks reversible?
What made Overkalix, Sweden, such an interesting place to study the connection between nutrition and health?
What connection was found between food supply of the grandfather and health of the grandson?
What was the effect of famine on the lifespan of the grandchild?
During what period of development was a man sensitive to epigenetic change? A woman? What can account for this difference?
What is meant by a 'trans-generational effect'?
In the study done on pregnant rats exposed to pesticide, the health effects for seen for how many generations? _____ Epigenetic tags were found in how many areas of the DNA? ______
What makes mapping the human epigenome even more complicated than the Human Genome Project?
After watching this video, what is your biggest concern or message?
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