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Speed and efficiency matter. Acetylcholine is rapidly destroyed by the enzyme acetylcholinesterase. This enzyme, which has a turnover number of 25,000 per second, has

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Speed and efficiency matter. Acetylcholine is rapidly destroyed by the enzyme acetylcholinesterase. This enzyme, which has a turnover number of 25,000 per second, has attained catalytic perfection with a kcat/KM of 2 108 Ms. Why is the efficiency of this enzyme physi- ologically crucial?

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