Step 5: The pairs above that are different are referred to as cis/trans (or more formally E/Z) isomers. Write a simple rule for double bonds to tell if there are cis/trans isomers or not. Make sure your answer is consistent with the examples above. Step 6: The cis/trans isomers examined above involve isomers of double bonds, of alkenes. The same terms, cis and trans, are used in a different context, for cyclic compounds with two groups (two substituents) attached to the ring. The example below, 1,2-dimethyloydohexane, is such a compound. might be or 1,2-dimethylcyclohexane cis (same side) trans (opposite side) The cis and trans isomer are referred to as diastereomers-they have the same connectivity, differ in the spatial arrangement of the atoms, but are not mirror images of each other. For each of the following compounds, draw the two possible lsomers and label them as cis or trans. Build models to help you see the differences. Example 1: Exampie 2: Example 3