"Study Says Coffee May Reduce Risk of Liver Disease" was a headline that appeared in USA Today. This conclusion was based on data from 494,000 people in the UK Biobank, a biomedical database The study monitored participants' liver health over an 11-year period and found that coffee drinkers were 21% less likely to develop chronic liver disease and 49% less likely to die of chronic liver disease than non-coffee drinkers. (a) Based on this study, is it reasonable to conclude that drinking coffee causes lower risk of liver disease? Explain. Yes. This was an observational study, but because it followed the same participants over time the conclusion is reasonable. Yes, because the sample is large enough to draw conclusions from. Yes, this was an experiment so it is reasonable to conclude that drinking coffee can lower risk of liver disease. No, this was an observational study, so cause-and-effect conclusions cannot be drawn. (b) Is it reasonable to generalize the results of this study to all American adults? Explain why or why not. Yes, because some the data would have come from American adults living in the UK. Yes, the UK has a similar culture and demographic distribution to the United States so it should be reasonable to generalize the results. No, because it is unclear whether all the participants were adults when the study began or not. No, because this data came from people in the UK and not from Americans.