: Suppose doses arecodedas follows:d1=-1.47, d2=-1.10, d3=-0.69,

d4=-0.42, d5=0, andd6=0.42. ThenassumingtheCRM methodas describedinthe

classnotesanswer:

(i) computetheprobabilityof atoxicityateachdose ? (answers:0.05, 0.1, 0.2,

0.3, 0.5, and0.7 atdoses 1 through7, respectively)

(ii)ifq =0.2 isour target,we assumeanexponentialprior for, andthefirstdose isd3, thendecidewhatthenextdose shouldbeineachof thefollowingcases:

(a) firstpatientexperiencesaDLT

(b) firstpatient does notexperienceaDLT.