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Suppose that a pharmaceutical company is interested in conducting a clinical trial to compare two cholesterol-lowering agents for the treatment of hypercholesterolemia patients. The primary
Suppose that a pharmaceutical company is interested in conducting a clinical trial to compare two cholesterol-lowering agents for the treatment of hypercholesterolemia patients. The primary efficacy parameter is low-density lipoprotein cholesterol (LDL-C). Suppose that a difference of 7% in the percent change of LDL-C is considered a clinically meaningful difference and that the standard deviation for the cholesterol- lowering agent for the treatment of hypercholesterolemia is assumed to be 14%. Assume the value of the significance level is 10%. (i) Write the null and alternative hypothesis (ii) Calculate the standard Effect Size (iii) Find the required total sample size of having power 90%
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