suppose that ten patients are considered where we wish to represent the patient's response y to drug B as a linear function involving her response x1 to drug A and heart rate x2. Using the data below

i 1 2 3 4 5 6 7 8 9 10

xi1 1.9 0.8 1.1 0.1 -0.1 4.4 4.6 1.6 5.5 3.4

xi2 66 62 64 61 63 70 68 62 68 66

yi 0.7 -0.1 -0.2 -1.2 -0.1 3.4 0 0.8 3.7 2.0

i. Fit a multiple linear regression model to this data

ii. complete the table of parameter estimate

iii. obtain the ANOVA table. what do you conclude at a=0.05

iv. From (ii) which of the predictor variables is not individually related to the patients response? support your answer

v. calculate the coefficient of multiple determination. What dies it include?