Question
Suppose that you have a friend who suffers from debilitating panic attacks that have not been helped by treatments that are currently on the market.
- Suppose that you have a friend who suffers from debilitating panic attacks that have not been helped by treatments that are currently on the market. Your friend's psychiatrist asks if he would like to participate in a clinical trial. There are two clinical trials available (Drug A or Drug B), and your friend asks you for help in deciding which drug seems more promising based on the available data.
- Although neither of the drugs are yet approved by the Food and Drug Administration (FDA), both are currently in the human trial stage of the approval process. The side effects for both drugs seem to be minor, and if your friend agrees to participate in one of the trials, all costs would be paid by a National Institutes of Health (NIH) research grant. The preliminary results from the trials are described below.
- Drug A information:In total, 250 participants took Drug A for 3 months, while another 250 participants took a placebo for 3 months in a double-blind study. While taking the "drug," the participants recorded the number of panic attacks they experienced. The mean number of panic attacks in the Drug A group wasM= 5.12,SD= 4.21,n= 250, while the mean number of panic attacks in the placebo group wasM= 6.87,SD= 4.62,n= 250,t(498) = 4.43,p< .001,d= .39. To participate in this trial, your friend would need to go to a local hospital once a week for a 1-hour visit.
- Drug B information:In total, 150 participants took Drug B for 3 months, while another 150 participants took a placebo for 3 months in a double-blind study. While taking the "drug," the participants recorded the number of panic attacks they experienced. The mean number of panicattacks in the Drug B group wasM= 5.47,SD= 2.89,n= 150, while the mean number of panic attacks in the placebo group wasM= 8.11,SD= 2.94,n= 150,t(298) = 7.84,p< .001,d= .70. To participate in this trial, your friend would need to go to a hospital that is approximately 45 minutes away once a week for 1.5-hour visits.
Which drug trial would you suggest to your friend? (You must choose one.)Explain your rationale;explain the relative importance of the respective sample sizes, the results of the hypothesis tests, the effect sizes, and the relative cost in terms of time commitment (e.g., travel time as well as treatment time). You should not just count the number of times that Drug A or B had "better results." You need to talk about which of these four factors is most important when deciding between these two drug trials and conclude your answer with a recommendation.
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