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Suppose you are examining two SNPs with the following allele frequencies in a given population: SNP 1 A 0.30 G 0.70 SNP 2 C 0.60

Suppose you are examining two SNPs with the following allele frequencies in a given population:


SNP 1A 0.30G 0.70
SNP 2C 0.60T 0.40


a. If these SNPs exhibit linkage equilibrium, what frequency of individuals carrying both ‘A’ and ‘T’ alleles would you expect to observe in the population?

b. Suppose you observe nearly twice as many ‘A’ and ‘T’ carriers than you expected. This may be due to human error in data collection or computation, recent mutations, natural selection, or error due to sampling from a large population. Reflecting on the material presented in this course, state one other possible reason for this observation.


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