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Hydrolysis of the N-glycosyl bond between deoxyribose and purine base in DNA creates an apurinic (AP) site. An AP site more thermodynamically destabilizing to a DNA molecule than is a mismatched base pair. Examine the structure of an AP site. Seleet the chemical consequences that could contribute to DNA instability at AP sites. disruption of the base-stacking interactions fewer hydrogen bonds between the unpaired pyrimidine base and water deereased interaction between the mutated DNA strand and histones inereased ability of the deoxyribose ring to open without the attachment of the purine base