The beginning of the twenty-first century marked the latest and deadliest wave of opioid abuse in American history, which is primarily tied to which two factors?

Group of answer choices

the rise in prescription opioid medications and the introduction of fentanyl

the rise in prescription opioid medications and the potency of heroin

the introduction of fentanyl and the refusal to treat opioid overdoses

the refusal to treat opioid overdoses and the low cost of heroin