Question
The following abbreviated abstract and table are from a paper published in JAMA ( JAMA. 2001; 285:2083-2093) entitled Lamivudine-Zidovudine Combination for Prevention of Maternal-Infant
The following abbreviated abstract and table are from a paper published in JAMA (JAMA. 2001; 285:2083-2093)entitled "Lamivudine-Zidovudine Combination for Prevention of Maternal-Infant Transmission of HIV-1".
ContextZidovudine reduces maternal-infant transmission of human immunodeficiency virus 1 (HIV-1) infection by two-thirds. Combination antiretroviral therapies are potentially more effective prevention.
ObjectivesTo assess the safety of perinatal lamivudine-zidovudine therapy, especially in children, and its effects on viral load, acquisition of drug resistance, and maternal-infant transmission of HIV-1.
Design and Settingan open-label, nonrandomized intervention trial conducted in the context of an ongoing observational cohort study in 48 sites in France.
PatientsA total of 452 HIV-1-infected pregnant women were enrolled as the study cohort; controls consisted of 910 pregnant women who had received zidovudine monotherapy as standard care.
Main Outcome MeasuresHIV-1 infection status and tolerance of therapy in children through age 18 months; maternal plasma HIV-1 RNA levels through 6 weeks after delivery.
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