The following is a formula for meperidine hydrochloride and clonidine hydrochloride for epidural injection

:

Meperidine HCl 0.375g

Clonidine HCl 0.75 mg

NaCl qs

Sterile Water for Injection qs 75 mL

The freezing point depression of 1% w/v meperidine HCl is 0.11C.

The freezing point depression of 1% w/v clonidine HCl is 0.19C

You do not have normal saline (NS) available to you. However, you do have concentrated 3% w/v NaCl solution. How many milliliters of the concentrated solution are required to make this formulation isotonic?Solve this question by answering part a-e

a)What is the freezing point depression from meperidine hydrochloride in this formulation?

Do not round intermediate steps

b)What is the freezing point depression from clonidine hydrochloride in this formulation?

Do not round intermediate steps

c) What additional freezing point depression, if any, is required after adjusting for the FP depression from other ingredients? Do not round intermediate steps

d)How many grams of NaCl are required to adjust the tonicity of this product?Do not round intermediate steps. Round final answer to three decimal places

e)How many milliliters of 3% w/v NaCl solution will provide the amount of NaCl calculated in part d? Do not round intermediate steps Round final answer to one decimal places