The following questions are based on the findings presented in Table 3 in the 2018 paper: (a) What can you say about the incidence rate for the primary endpoint across the intervention arms? (b) Calculate the basic incidence density ratio comparing: - mediterranean diet with EVOO to control condition - mediterranean diet with nuts to control condition (c) Interpret what the incidence density ratios calculated in (b) mean: - mediterranean diet with EVOO to control condition - mediterranean diet with nuts to control condition

Table Estimates of Cardiovascular Events According to Intervention Group, Mediterranean Diet with VOO IN-2543) 11852 Mediterranean Dirt with Nuts (N-2454) 10365 Control Diet IN-24501 9763 End Point No. of persons of follow up Primary end pointt No of events Incidence rate per 1000 persony (95% CI) Syr absoluterisk -% (95% CI: Secondary end points 96 8.16.6-9.91 3.6 2.8-4.5) 8) 8.0 (6.4-9.91 1.0 (3.1-5.01 109 11.2 19.2-13.5) 5.7146-6.9) 32 4.1 13.1-5.5) 1.7 1.3-2.4) 3.1 2.1-441 1.5 (1.1-23) 58 5.945-2.7) 3.0 (23-3.9) 31 38 3.1 122-43) 1.4 1.0-2.1) 3.02.0442) 1.5 (1.1-23) 2.1 (1.5-2.5) 26 2.2 (1.4 3.2) 1.0 (0.6-1.5) 31 3.0 (2.0-4.2) 1.4 (0.9-21) 30 3.1 (21-44) 1.6 (1.1-2.3) 118 10.08.2-11.9 11.2 (9.3-13.4) 54(44-661 11.7 19.6-14.01 5.414467) No. of events Incidence rate per 1000 person yr 195% CI) 5-yr absolute risk -% (95%) Myocardial infarction No. of events Incidence rate per 1000 person yr 19% CI) 5.yt absoluterisk - % (95%) Death from cardiovascular causes No. of events Incidence rate per 1000 persons (95% CI) 5-yr absoluterisk -% (95% CI) Death from any cause No. of events Incidence rate per 1000 persos (95% CI) 5.yr absolute risk - [95%CI) IT analysis: hazard ratio for each Mediterranean diet vs. control (95% CI) Primary and point Leadjusted Ad usted Secondary end points Stroke Myocardial infarction Death from cardiovascular causes Death from any cause ITT analysis: hazard ratio for Mediterranean diets combined vs. control (95% CIS Primary end point Leadjusted Adjusted Secondary end points Stoke Myocardial infarction Death from cardiovascular causes Death from any cause 0.70 (0.51 0.92) 0.69 0.53 091) 0.70 (0.53-0.94) 0.72054-095) 1.00 1.00 (ref) 0.65 0.44-0.95) 0.82 (0.52-1.30) 0.62 (0.36-1.06) 0.90 (069-1.15) 0.54 (0.35-0.82) 0.76 (0.47-1.25) 1.02061-16) 1.12 10.85-1.47) 1.00 (red) 1.00ff 1.00 (ef) 1.00) 0.70 (0.55-0.89) 0.70 (0.55-0.89) 1.00) 1.00 (red) 0.58 (0.42-0.82) 0.90 (0.5)-1.21) 0801051-1.24) 0.98 (0.77-124) 1.00) 1.00 1.00 tref 1.00 tref Table Estimates of Cardiovascular Events According to Intervention Group, Mediterranean Diet with VOO IN-2543) 11852 Mediterranean Dirt with Nuts (N-2454) 10365 Control Diet IN-24501 9763 End Point No. of persons of follow up Primary end pointt No of events Incidence rate per 1000 persony (95% CI) Syr absoluterisk -% (95% CI: Secondary end points 96 8.16.6-9.91 3.6 2.8-4.5) 8) 8.0 (6.4-9.91 1.0 (3.1-5.01 109 11.2 19.2-13.5) 5.7146-6.9) 32 4.1 13.1-5.5) 1.7 1.3-2.4) 3.1 2.1-441 1.5 (1.1-23) 58 5.945-2.7) 3.0 (23-3.9) 31 38 3.1 122-43) 1.4 1.0-2.1) 3.02.0442) 1.5 (1.1-23) 2.1 (1.5-2.5) 26 2.2 (1.4 3.2) 1.0 (0.6-1.5) 31 3.0 (2.0-4.2) 1.4 (0.9-21) 30 3.1 (21-44) 1.6 (1.1-2.3) 118 10.08.2-11.9 11.2 (9.3-13.4) 54(44-661 11.7 19.6-14.01 5.414467) No. of events Incidence rate per 1000 person yr 195% CI) 5-yr absolute risk -% (95%) Myocardial infarction No. of events Incidence rate per 1000 person yr 19% CI) 5.yt absoluterisk - % (95%) Death from cardiovascular causes No. of events Incidence rate per 1000 persons (95% CI) 5-yr absoluterisk -% (95% CI) Death from any cause No. of events Incidence rate per 1000 persos (95% CI) 5.yr absolute risk - [95%CI) IT analysis: hazard ratio for each Mediterranean diet vs. control (95% CI) Primary and point Leadjusted Ad usted Secondary end points Stroke Myocardial infarction Death from cardiovascular causes Death from any cause ITT analysis: hazard ratio for Mediterranean diets combined vs. control (95% CIS Primary end point Leadjusted Adjusted Secondary end points Stoke Myocardial infarction Death from cardiovascular causes Death from any cause 0.70 (0.51 0.92) 0.69 0.53 091) 0.70 (0.53-0.94) 0.72054-095) 1.00 1.00 (ref) 0.65 0.44-0.95) 0.82 (0.52-1.30) 0.62 (0.36-1.06) 0.90 (069-1.15) 0.54 (0.35-0.82) 0.76 (0.47-1.25) 1.02061-16) 1.12 10.85-1.47) 1.00 (red) 1.00ff 1.00 (ef) 1.00) 0.70 (0.55-0.89) 0.70 (0.55-0.89) 1.00) 1.00 (red) 0.58 (0.42-0.82) 0.90 (0.5)-1.21) 0801051-1.24) 0.98 (0.77-124) 1.00) 1.00 1.00 tref 1.00 tref