The incentive compensation systems for trade marketing and sales personnel were quite different. Incentives for trade marketing personnel were based on CAGP profit before tax (PBT) (40% weighting), the profit contribution of the brands managed (20%) and other objectives tailored to the role (40%). In contrast, incentives for field sales personnel were based on sales volume (75%) and CAGP PBT (25%). Target bonuses were generally around 15% of base salary for lower-level marketing personnel and 20-22% for lower-level sales personnel. Managers at higher organizational levels had higher target bonuses. The bonus opportunities were highly leveraged. No bonuses were paid for if targets were not close to being achieved (e.g. 90% of target). Exceeding targets could result in bonus payouts several times the target bonus (e.g. exceeding the target by 5% would sometimes more than double the bonus payout)

131 If a female patient with multiple sclerosis wants to become pregnant, what are the risks, family planning advice and treatment, etc? What is the best advice to give to her?

132 Is there a role for methotrexate and azathioprine in the treatment of remitting-relapsing multiple sclerosis?

133 Do steroids have a role in preventing or ameliorating the relapses in relapsing-remitting multiple sclerosis?

134 Has cyclophosphamide a role in decreasing the rate and number of relapses in relapsing-remitting multiple sclerosis?

135 Is there evidence of the efficacy of cyclic pulse cyclophosphamide therapy in the treatment of relapsing-remitting multiple sclerosis?

136 Glatiramer acetate and interferon-beta are recommended by some people for the treatment of multiple sclerosis. Which drug should I use for a patient with a 2-year history of relapsing-remitting MS.

137 1. Most neurological books available to me say that high-dose IV dexamethasone can be used in acute relapses of multiple sclerosis (MS). What is the recommended dosage and regimen for this drug? 2. I understand that depot preparations of betamethasone (Depofos) can also be used in acute relapses of MS, as well as treatment for idiopathic Bell's palsy. If so, can you tell me the recommended dosage and regimen for this drug?

138 What are the most common causes of chronic meningitis and what investigations must be done?

139 What is Hib meningitis?

140 How often is tuberculosis a cause of chronic meningitis in comparison to other causes?