The main difference between Commercial Banks and Thrifts is:

Banks usually have about three-fourths of their liabilities carried as Deposits from Customers; thrifts don't.

The largest part of a thrift's asset base is in mortgage loans, while banks have a more diversified loan portfolio.

Banks can hold demand deposits accounts; thrifts can't.

Commercial banks are larger in asset size than thrifts.

Thrifts cannot have interstate banking but commercial banks can.