The marketer estimated that the number of PAO patients in the United States in 2021 was 110,000 and would grow exponentially. Since similar data for Canada, Europe were not available, the marketer estimated that the number of PAO patients in these regions would be proportional to the population in those countries. Canada and Europe are anticipated to have 10%, and 100% of the United States patients, respectively. The number of PAO patients in these three regions grows 0.5%, annually