The medical evidence is clear: Cervical cancer screening saves lives. Much of the focus of cost-effectiveness research addresses issues concerning the appropriate screening interval. D.M. Eddy (Screening for cervical cancer,Annals of Internal Medicine113, 214-226, 1990) studied the issue and estimated that annual screening for a hypothetical cohort of 1,000 22-year-old women screened until age 75 would cost $1,093,000 and would save 27.6 life years. If screened every three years instead, the cost would be $467,000 and 26.8 life years would be saved. Is annual screening cost effective?