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The roundworm Caenorhabditis elegans is a widely studied animal model, in part because of its small number of neurons and easily manipulated genome. Nociception

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The roundworm Caenorhabditis elegans is a widely studied animal model, in part because of its small number of neurons and easily manipulated genome. Nociception is the neural perception of an actually or potentially harmful stimulus. In C. elegans, it evokes a self-preserving withdrawal behavior. However, repeated stimulation can result in reduced withdrawal response, or habituation. Researchers compared the withdrawal response to disturbing light stimuli in wild-type C. elegans and a mutant C. elegans line that exhibits a slower response of sensory neurons (PVD). The given scatterplot shows the data of the percent of animals tested that exhibited a withdrawal reaction to a noxious stimulus consisting of varying numbers of consecutive light pulses. Failure to react indicates habituation. Circles represent wild-type C. elegans, and squares represent the mutant line. 100 60- Percent of animals reacting 8 40 Wild type Mutant 20 20 Number of light pulses 1. S.J. Husson et al., "Optogenetic analysis of a nociceptor neutron and network reveals ion channels acting downstream of primary sensors," Current Biology 22 (2012), pp. 743-753. doi:10.1016/j.cub.2012.02.066. Macmillan Learning What does the scatterplot show about the pattern of withdrawal responses in wild-type C. elegans for increasing numbers of light pulses? How does your answer fit in the context of habituation? What does the scatterplot show about the pattern of withdrawal responses in wild-type C. elegans for increasing numbers of light pulses? How does your answer fit in the context of habituation? The negative linear association in the wild-type C. elegans does not indicate habituation: The response to the harmful stimulus is more pronounced when the stimulus is applied more times. The negative linear association in the wild-type C. elegans does not indicate habituation: The response to the harmful stimulus is less pronounced when the stimulus is applied more times. The negative linear association in the wild-type C. elegans indicates habituation: The response to the harmful stimulus is more pronounced when the stimulus is applied more times. The negative linear association in the wild-type C. elegans indicates habituation: The response to the harmful stimulus is less pronounced when the stimulus is applied more times.

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