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There are different types of product inhibition depending on the mechanism by which the product inhibits further production. Here, we look at a type

There are different types of product inhibition depending on the mechanism by which the product inhibits

There are different types of product inhibition depending on the mechanism by which the product inhibits further production. Here, we look at a type of product inhibition where the product P binds to the enzyme-substrate complex and forms the inactive product-enzyme-substrate complex P:E:S. We assume in this task that only the enzyme-substrate complex E:S can produce more product P. The following reaction scheme describes this system: kon 2 koff E:S Keat E+P P:E:S E+S P + E:S kass kdis E:S Below, we want to derive a reduced ODE for the concentration of product P. We will assume that the dynamics of the complexes E:S and P:E:S are fast and can therefore be approximated by their quasi-steady state concentrations.

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