Trade marketing also set up deal parameters as guidelines for sales when they planned and executed merchandising deals with accounts. Deal parameters could relate to the lowest unit price at which a product could be offered to a customer, the dates of a deal, or the values allowed on the discount coupons retailers ran in their own in-store advertisements. Before implementing exceptions to the established deal parameters, sales managers had to secure the approval of the appropriate trade-marketing manager.

111 What is the maintenance dose of phenytoin in seizures arising as a complication of chronic renal failure?

112 I know that the loading dose of phenytoin in status epilepticus is 20 mg/kg with an upper limit of 1000 mg but if the same situation arose as a complication of chronic renal failure (on regular dialysis), should this dose remain the same or be reduced? If reduced, what should the dose be?

113 1. What is the most effective antiepileptic for a patient with simple partial motor status epilepticus who is not responding to a loading dose of phenytoin? 2. How long does phenytoin, given in a loading dose, take to work?

114 Is valproate effective if given rectally in status epilepticus and, if so, what dose is recommended? Ques

tion 115 In simple partial motor status epilepticus, if the patient does not respond to diazepam and phenytoin, is it justifiable to proceed to anaesthetic medication?

116 What is the recommended upper limit dose of lamotrigine when combined with both carbamazepine and valproate?

117 Is a valproate-lamotrigine combination more effective than carbamazepine on its own against partial seizures?

118 Why is the incidence of parkinsonism less common in smokers?

119 Is it recommended to start the treatment of parkinsonism with dopamine agonists alone in elderly (over 60 years old) patients, and to delay using L-dopa until the disease has progressed much further? Is there a rationale for this protocol in younger patients?

120 Does amantadine increase the endogenous release of dopamine, thus aiding early treatment of parkinsonism?