vi$.$ In a research laboratory a researcher working on metabolism of yeast has found the entropy of components A and $B$ as $7\mathrm{.}5$ and $4\mathrm{.}5kJk{g}^{-1}{K}^{-1}$ respectively which is involved in the reaction $AB.$ Researcher claims the reaction to be spontaneous under in$-$vivo conditions, but was unable to carry out the reaction under in$-$vitro conditions. The researcher is approaching you to identify the reason for the failure in view of thermodynamic concepts. Identify and explain the reason with proper justification.