were seven-even though only some pregnant Muslims observe the fast. The negative effect on school performance was of similar size to the positive one associated with America's Head Start, an early-years education programme. One explanation for such ill effects is that poor prenatal health retards the growth of the fetus or causes premature birth. Pregnant women who live in areas with badly polluted air are more likely to give birth early and their children are on average smaller. Underweight newborns are more prone to the same types of ills that are linked to fetal-origins effects Nurture meets nature But not all of the long-term harm caused by prenatal suffering can be linked to birth weight, suggesting that something else is at work One theory is that adversity during pregnancy "switches on" genes that predispose an unborn child to chronic illness. The long-vaunted distinction between nature and nurture is therefore "outdated and unhelpful", says Janet Currie of Princeton University's Centre for Health and Child Wellbeing. Poor nurture during pregnancy can worsen the hand that nature has dealt. One sobering conclusion is that children born to poor mothers are at an even greater lifelong disadvantage than previously thought. Poorer people are more likely to go hungry and less likely to know what pregnant women should eat. In America, nearly a third of black, unmarried expectant mothers who did not graduate from high school gain less than the recommended amount of weight during their pregnancies-twice as high as the share for white, married women with college education. A life in poverty is all too often a life of chronic stress. American women who earn less than $25,000 a year are two-and-a-half times more likely to suffer domestic violence than those who earn more. Not even past Education and income of American men in 1980 Average years of schooling 12.0 11/5 10.5 10.0 barof hurtin 1912 14 15 18 20 22 Average personal income Constant 1080 5 000 12 10 Saraf harm 1912 16 18 20 22 Source: "Is the 1938 Influenza Pandemic (her!", by Du Almond. ABER Working Paper, July 2005In developing countries newborn babies face a wide range of hazards that they were protected from in the womb, at least partly. These include dirty water, gross undernourishment and infectious disease. That is why development experts emphasise the importance of the "first 1,000 days"-the nine months spent in the womb and the first two years outside it. In the rich world. small babies face fewer risks. The time spent in utero is therefore relatively more significant. But in the fetal-origins hypothesis there also lies one policy advantage. Many of the stresses known to damage fetuses can be ameliorated by better health education, nutrition supplements and targeted subsidies. Food vouchers have been shown to reduce the incidence of low birth weight among poorer women. Tanzanian children who were in utero during iodine-supplement programmes did better in school; the gains were equivalent to six months of extra schooling. A monthly nurse-visiting scheme in America for poor unmarried first-time expectant mothers, which started when they first came to a clinic for prenatal care and continued until their children turned two, led to fewer delinquent adolescents. It can take a long time for environmental policies to have an impact. But housing subsidies that allow poor pregnant women to move away from highly polluted areas can help fast. Even stress during pregnancy can be reduced. In America and Canada, cash transfers to poor families with young children have improved mothers' mental health. An American law that mandated 12 weeks of unpaid maternity leave for some working women cut the incidence of premature births. Cracking down on domestic violence by reducing the discretion of police and prosecutors not to proceed with cases, and increasing community resources for victims, have also led to higher birth weight. Making sure women realise early that they are pregnant can help to avoid unnecessary risks. Nearly half of pregnancies in Britain are unplanned, and many women binge-drink before they know they have conceived. Alaska is installing free pregnancy-test dispensers in bars in an attempt to cut the rate of fetal-alcohol syndrome. Increasing access to family planning by including contraception in health-insurance programmes for the poor can help make unintended pregnancies rarer. Well-designed and targeted interventions can be very cost-effective, points out Douglas Almond of Columbia University. Fetal-origins effects are often large-and pregnancy, after all, lasts just nine months.Prenatal health and life outcomes: Unequal beginnings A child's long-term well-being is more profoundly shaped by influences in pregnancy than used to be realised Apr 4th 2015 HALF a century ago doctors saw the fetus as a "perfect parasite"-absorbing what it needed but sealed off in the womb from any harm done to the mother. About half of American women smoked through pregnancy. When babies were born with the damage now described as fetal- alcohol syndrome, heredity was blamed. Since then it has become a commonplace that healthy habits and good nutrition during pregnancy make it less likely that a baby will be born early, underweight or ill. Now a growing body of research is showing that problems caused by the prenatal environment may not be apparent at birth, but can resonate throughout life. Infections, hunger, stress and air pollution have been implicated in a host of long-term problems for those exposed to them in utero, including bad health, poor school results and lower earnings. Even relatively minor exposure can increase the odds of suffering from chronic disease or disability. Long-term consequences, by definition, take time to become apparent. And pregnant women cannot be randomly assigned to suffer different types of adversity-which can, anyway, be correlated either with each other or with inherited traits. So some of the strongest evidence has come from comparing those in the womb during sudden calamities such as famines, natural disasters and environmental accidents with those born just before or after. This approach untangles the effects of environment from those of genes or upbringing. Comparisons between entire cohorts should mean that those who were affected are the same as those who were not in every respect except their environment. That permits researchers to draw inferences about the effects of harms inflicted in utero on individuals rather than groups. The 1918 influenza pandemic affected a third of all American women of child-bearing age. Fifty years on, those who had been in the womb at the time had done worse in school and were earning less than those slightly older or younger. The men were 20% more likely to be disabled. Similarly, babies born to Dutch women who were pregnant during the 1944-45 "hunger winter", when the Nazis blocked shipments of food to the occupied western provinces of the Netherlands, were more prone in adulthood to a host of health problems, including obesity, heart disease, diabetes, schizophrenia and depression. And Swedes born in the months after the 1986 Chernobyl nuclear accident, which sent radiation-bearing dust clouds across swathes of the country, were 40% more likely to fail in middle school than those born just before or after, even though they were exposed to radiation at doses now considered harmless, and their physical health did not seem to be affected. Less extreme events can also have long-term effects. A study from Sweden found that the children of women who had lost a relative while pregnant grew up to be more likely to suffer attention deficit disorder, anxiety or depression. Another, of Bangladeshi and Pakistani families in England, found that children whose first trimester in the womb coincided with Ramadan when observant Muslims fast from sunrise to sunset, lagged behind educationally when they